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70602. Damaris 06-03-2020, 06:36:56
email  homepage Such humanized or human monoclonal antibodies can be prepared and isolated as  
described herein. In other embodiments, the antibodies are, for example, chimeric monoclonal antibodies. 
In another embodiment, the anti-ICOS antibody is administered, 
for example, within about 30 minutes of the second antibody. 
 
Thus, a first antibody, e.g., the anti-ICOS antibody, 
and a second, third, or more antibodies can be simultaneously administered in a single formulation. To create a humanized antibody, the  
CDR regions can be inserted into a human framework using methods known in the art (see e.g., U.S. 
In some embodiments, when V.sub.H CDR sequences are mixed and matched, the CDR1, CDR2 and/or CDR3 sequence from a particular V.sub.H sequence is replaced with a structurally similar CDR sequence(s). 
The nucleic acid and protein sequences described herein can further be used as a "query sequence" to perform a search against public databases, for example,  
to identify related sequences. One or more amino acid residues in the protein may  
contain a modification such as, but not limited to, glycosylation, phosphorylation or a disulfide bond.
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